Profhilo Vs Polynucleotides

May 27, 2025

Profhilo vs. Polynucleotides: Which is Right for You?

Both Profhilo and polynucleotides are injectable treatments that improve skin quality, but they work in different ways:

Profhilo is a hyaluronic acid-based treatment that deeply hydrates the skin, boosts collagen, and gives a natural, glowing lift – ideal for dull, dry, or sagging skin.

Polynucleotides use DNA fragments to repair and regenerate the skin at a cellular level – perfect for sensitive, inflamed, or damaged skin, including acne scarring and pigmentation.

Which One Should I Choose?

Choose Profhilo if:

• Your skin feels dry, or tired

• You want an overall glow-up with quick results

• You’re new to injectable treatments

Choose Polynucleotides if:

• Your skin is inflamed, stressed, or showing early signs of aging

• You have acne scarring, pigmentation, or sensitivity

• You want long-term regeneration and healing

Still not sure? Our expert practitioners at Innerene Aesthetics Medical are here to guide you through a bespoke consultation and help you choose the best treatment for your individual needs. Want both? They can be combined for even better results. Book a consultation to find out what’s best for your skin.

Frequently Asked Questions

Q: Do Profhilo and polynucleotides hurt?

Both treatments involve a series of small injections, but discomfort is minimal. A numbing cream can be applied beforehand if needed.

Q: How soon will I see results?

Profhilo results can be seen within a few weeks – skin looks smoother and more radiant. Polynucleotide results are more gradual, as they work deeper to repair the skin, with visible improvements over a few months.

Q: Can I have both treatments?

Yes, absolutely. In fact, they can complement each other beautifully. Your practitioner will help design a treatment plan tailored to your skin’s needs.

Q: Is there any downtime?

You may experience mild redness, swelling, or small bumps at the injection sites for a day or two, but most clients return to normal activities the same day.

Q: Will I need more than one treatment?

Yes, for Profhilo you will need 2 treatments spaced 4 weeks apart and then repeated every 6 months in order to maintain the results.

Polynucleotides we reccomend a course of 3 treatments spaced 3 weeks apart an inital course of treatments

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